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Journal Articles
Journal of Experimental Medicine (2019) 216 (5): 10161026.
Published: 11 April 2019
...Nicole M. Aiello; Yibin Kang Epithelialmesenchymal transition (EMT) is a developmental process whereby stationary, adherent cells acquire the ability to migrate. EMT is critical for dramatic cellular movements during embryogenesis; however, tumor cells can reactivate EMT programs, which increases...
Journal Articles
Journal of Cell Biology (2018) 217 (8): 27272742.
Published: 18 May 2018
Includes: Supplementary data
Journal Articles
Journal of Experimental Medicine (2014) 211 (7): 13791391.
Published: 09 June 2014
Includes: Supplementary data
Journal Articles
Journal of Experimental Medicine (2014) 211 (8): 16371655.
Published: 07 July 2014
... virus-specific CD8 T cell response. Although prolonged Ag presentation did not alter the number of memory CD8 T cells that developed, it was essential for programming the capacity of these cells to proliferate, produce cytokines, and protect the host after secondary challenge. Importantly, prolonged Ag...
Includes: Supplementary data
Journal Articles
Journal of Cell Biology (2012) 197 (2): 253266.
Published: 16 April 2012
.... Using single molecule analysis of replicated DNA (SMARD), we delineate the replication programs—i.e., origin distribution, termination site location, and fork rate and direction—of specific telomeres/subtelomeres of individual human chromosomes in two embryonic stem (ES) cell lines and two primary...
Includes: Supplementary data
Journal Articles
Journal of Cell Biology (2009) 185 (1): 1119.
Published: 30 March 2009
... metastatic programs by trafficking through a stromal extracellular matrix (ECM) dominated by cross-linked networks of type I collagen, the major extracellular protein found in mammals ( Brown et al., 2003 ; Sabeh et al., 2004 ; Demou et al., 2005 ; Oldberg et al., 2007 ; Magzoub et al., 2008 ). To...
Journal Articles
Journal of Cell Biology (2009) 184 (3): 399408.
Published: 02 February 2009
... programs such as gastrulation ( Carver et al., 2001 ; Nieto, 2002 ; Murray et al., 2007 ). Snail1 triggers this transdifferentiation program, in part, by repressing epithelial markers and related cellcell junction proteins while coordinately acting as a major cytoskeletal regulator ( Batlle et al., 2000...
Includes: Supplementary data
Journal Articles
Journal of Cell Biology (2006) 175 (4): 607617.
Published: 20 November 2006
... death machinery programming cell apoptotic response to environmental changes ( Davis, 2000 ; Weston and Davis, 2002 ; Lin, 2003 ), has recently been proposed as a key mechanism for the antiapoptotic action of NF-κB under multiple cellular stresses, including the transformation conditions ( Bubici et...
Images
CSF-1 and IL-34 drive distinct microglial <b>programs</b> in the brain tissue. (A)...
Published: 26 July 2019
Figure 2. CSF-1 and IL-34 drive distinct microglial programs in the brain tissue. (A) Hierarchical clustering (left) and select representative genes (right) from 860 DEGs between P8 Csf1 fl/fl and Nes Cre Csf1 fl/fl cerebellar microglia. (B) Normalized expression (RPKM) of select immune More
Journal Articles
Journal of Cell Biology (2005) 168 (4): 607618.
Published: 14 February 2005
... neurotoxin C1 (BoNT/C) in central nervous system neurons activates distinct neurodegenerative programs in the axo-dendritic network and in the cell bodies. Neurites degenerate at an early stage by an active caspase-independent fragmentation characterized by segregation of energy competent mitochondria. Later...
Journal Articles
Journal of Cell Biology (2000) 151 (7): 15011512.
Published: 25 December 2000
... horseradish peroxidase (SigmaAldrich) used at a dilution of 1:2,500. Blots were developed using the ECL Western blotting detection system (Amersham Pharmacia Biotech). Autoradiographs were scanned and the protein bands were quantitated using the MacBAS V2.5 program. JC1296 carrying pJC1869 (prom...
Journal Articles
Journal of Experimental Medicine (1999) 190 (6): 749756.
Published: 20 September 1999
... cells 1 2 3 4 . Findings that immature B cells are exquisitely sensitive to tolerance induction compared with mature B cells 5 6 7 suggest that antigenreceptor signaling may be qualitatively or quantitatively distinct in these populations. Although developmentally programmed differences in B...
Images
TRAF3IP3 regulates T reg cell effector <b>programs</b> and stability. (A��C) Splen...
Published: 16 August 2018
Figure 4. TRAF3IP3 regulates T reg cell effector programs and stability. (AC) Splenic T reg cells obtained from Traf3ip3 +/+ Foxp3 -Cre (wild-type [WT]) mice and Traf3ip3 fl/fl Foxp3 -Cre (KO) were stimulated with anti-CD3 and anti-CD28 antibodies for 24 h and subjected to RNA sequencing More
Journal Articles
Journal of Experimental Medicine (2019) 216 (6): 14111430.
Published: 29 April 2019
Includes: Supplementary data
Journal Articles
Journal of Experimental Medicine (1998) 187 (6): 875883.
Published: 16 March 1998
... CCR7 expression, whereas interferon α inhibited CCR3 but upregulated CXCR3 and CCR1. These results demonstrate that chemokine receptors are markers of naive and polarized T cell subsets and suggest that flexible programs of chemokine receptor gene expression may control tissue-specific migration of...
Journal Articles
Journal of Experimental Medicine (2019) 217 (1): e20191030.
Published: 30 September 2019
... antagonized type 1 programming, largely through restraint of T-bet expression and function. Mapping of the dynamic changes in chromatin landscape accompanying CCR6 ? ILC3 development and ILC1 conversion solidified c-Maf as a gatekeeper of type 1 regulatory transformation and a controller of ILC3 fate...
Includes: Supplementary data
Journal Articles
Journal of Cell Biology (1996) 132 (5): 849859.
Published: 01 March 1996
... SM22alpha-lacZ transgene was therefore able to distinguish between the transcriptional regulatory programs that control gene expression in vascular and visceral SMCs and revealed heretofore unrecognized differences between these SMC types. These results suggest that distinct transcriptional regulation...
Journal Articles
Journal of Cell Biology (1995) 131 (6): 15731586.
Published: 15 December 1995
... activated the Met receptor by phosphorylation of tyrosine residues. These data show that HGF/SF induces intrinsic, tissue-specific morphogenic activities in a wide variety of epithelial cells. Apparently, HGF/SF triggers respective endogenous programs and is thus an inductive, not an instructive...
Journal Articles
Journal of Cell Biology (1992) 117 (4): 825839.
Published: 15 May 1992
... associated with increases in crypt cell proliferation but had no apparent effect on commitment to differentiate along enterocytic, enteroendocrine, or Paneth cell lineages. Single- and multilabel-immunocytochemical studies plus RNA blot hybridization analyses suggested that the differentiation programs of...
Journal Articles
Journal of Cell Biology (1990) 111 (3): 11491159.
Published: 01 September 1990
... pattern of sarcomeric MHCs. Myogenic Programs of Mouse Muscle Cell Lines: Expression of Myosin Heavy Chain Isoforms, MyoD1, and Myogenin Jeffrey Boone Miller Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129; and Program in Neuroscience...